The CUBE guide us to practical solutions for the pharma industry
X - Application
Y - Process Mode
Z – Technology
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X - Application
- Protein expression = secretion of molecules such as proteins by micro-organism.
- Cell Proliferation = fast unlimited multiplication of identical micro-organism.
Y - Process mode within your interest
- Continuous Cultivation / Perfusion = steady state conditions with constant media flow exchange and constant harvest flow.
- Cell Retention / Perfusion = “protein expression” based on; 1. Sequential harvest of product from micro-organism, 2. Sequential removal of micro-organism, 3. Sequential media exchange.
- Batch and Fed-batch = 1. Batch operation to which no fresh media is added and no broth is removed, 2. Fed-batch to which fresh medium is added and no broth is removed before process termination.
Z - Technologies within our processing
- Reactor's = Stirred-Tank-Reactors, Fixed-Bed-Reactors, Scaffolding-Reactor, Cell-Retention-Reactor, Perfusion-Reactor, Fermenter, Bioreactor - preferably of Single-Use design.
- Sensor's = for on-line monitoring of process parameters as input to PCS - preferably of Single-Use design.
- Pump's = devices for conveying, moving, exchanging fluids or perform harvest by fluid controlling means - preferably of Single-Use design.
- Process-Control-System's (PCS) = digital computer power used for control of processes via sensor input and actuator output.